| Date | Event | Significance |
| 753 BC | Traditional founding of Rome by Romulus. | The founding date of the city on the Palatine; the beginning of Roman history. |
| c. 750 BC | The "Rape of the Sabine Women" (tradition). | The legendary union of Rome with the Sabines; founding of Roman institutions of marriage and the gentes. |
| 715–673 BC | Reign of Numa Pompilius. | Founding of Rome's religious institutions, calendar and priesthoods. |
| c. 630 BC | Foundation of the colony of Rome on the coast (Ancus Marcius founds Ostia). | Rome gains a port command at the mouth of the Tiber. |
| 578–535 BC | Reign of Servius Tullius; the census and centuriate assembly. | The reform that organised the army and citizen body by wealth; foundation of the later centuriate assembly. |
| 509 BC | Expulsion of Tarquin the Proud; founding of the Republic; first consulship of Brutus and Collatinus. | Abolition of the monarchy; the birth of the Roman Republic and of republican "liberty." |
| Date | Event | Significance |
| c. 494 BC | First Secession of the Plebs; creation of the tribunes. | The plebeians win their champions; the beginning of the Struggle of the Orders. |
| c. 451–450 BC | The Law of the Twelve Tables. | The first written code of Roman law; the foundation of the legal tradition. |
| c. 449 BC | Second Secession; fall of the Decemvirate (story of Verginia). | Restoration of the consulship; consolidation of plebeian rights. |
| 390 BC | Sack of Rome by the Gauls under Brennus. | Destruction of the city; its recovery and rebuilding under Camillus ("second founder"). |
| 367 BC | The Licinian-Sextian laws. | Plebeians admitted to the consulship; end of the patrician monopoly. |
| 343–290 BC | The Samnite Wars. | Roman conquest of central-southern Italy. |
| 340–338 BC | The Latin War. | Roman mastery of Latium; dissolution of the Latin League. |
| 312 BC | Appius Claudius builds the Appian Way. | The first great Roman road; symbol of Roman engineering and of the road system. |
| 287 BC | The lex Hortensia. | Plebiscites (votes of the plebeian assembly) become binding on all; end of the Struggle of the Orders. |
| 280–275 BC | The war against Pyrrhus of Epirus. | Roman victory over a Greek king; mastery of Italy complete; "Pyrrhic victory" enters the language. |
| Date | Event | Significance |
| 264 BC | Outbreak of the First Punic War. | Rome's first war against Carthage; the conflict for Sicily that made Rome a Mediterranean power. |
| 241 BC | Roman naval victory at the Aegates Islands; end of the First Punic War; Sicily becomes a province. | Rome's first province; Carthage's humiliating defeat that bred the Barcids' revenge. |
| 218 BC | Outbreak of the Second Punic War; Hannibal crosses the Alps. | The invasion of Italy by the greatest general of antiquity. |
| 217 BC | Battle of Lake Trasimene. | Hannibal destroys a Roman army in an ambush; death of Flaminius. |
| 216 BC | Battle of Cannae. | The worst defeat in Roman history; Hannibal's double envelopment; Rome refuses to surrender. |
| 212 BC | Roman capture of Syracuse (Marcellus). | The conquest of the great Greek city; death of Archimedes. |
| 207 BC | Battle of the Metaurus. | Destruction of Hasdrubal's army; the doom of Hannibal's campaign in Italy. |
| 202 BC | Battle of Zama. | Scipio Africanus defeats Hannibal; end of the Second Punic War; Carthage's power broken. |
| 197 BC | Battle of Cynoscephalae. | Roman defeat of Philip V; end of Macedonian power in Greece. |
| 196 BC | Proclamation of Greek "freedom" by Flamininus. | Roman suzerainty over Greece began to be established. |
| 190 BC | Battle of Magnesia. | Roman defeat of Antiochus III; end of Seleucid power in Asia Minor. |
| 168 BC | Battle of Pydna. | Defeat and capture of Perseus; the abolition of the Antigonid kingdom of Macedon; Rome's mastery of the east complete. |
| 149–146 BC | Third Punic War. | The final war against Carthage. |
| 146 BC | Destruction of Carthage; sack of Corinth. | The end of Carthage and of Greek independence; Rome the unchallenged master of the Mediterranean. |
| Date | Event | Significance |
| 133 BC | Tribunate and murder of Tiberius Gracchus. | The beginning of a century of political violence in Rome. |
| 123–121 BC | Reforms and death of Gaius Gracchus. | Widening of the reform programme; the Senate uses force against a tribune. |
| 107 BC | Marius recruits the landless into the army; the Jugurthine War. | Creation of the professional army; the rise of the powerful general. |
| 102–101 BC | Marius defeats the Cimbri and Teutones at Aquae Sextiae and Vercellae. | Rome saved from the Germanic peoples; Marius at the height of power. |
| 91–88 BC | The Social War. | Revolt of the Italian allies; citizenship extended to them; rise of Sulla. |
| 88 BC | Sulla marches on Rome. | The first use of the army against the state; a fatal precedent. |
| 82 BC | Sulla becomes dictator; the proscriptions. | Mass killing of political enemies; Sulla's reform of the constitution. |
| 73–71 BC | The slave revolt of Spartacus. | The greatest slave rebellion; crushed by Crassus. |
| 60 BC | The First Triumvirate (Caesar, Pompey, Crassus). | The private alliance that broke the Senate's monopoly of power. |
| 58–50 BC | Caesar's conquest of Gaul. | The addition of all of Gaul to the empire; Caesar's rise to supreme power. |
| 52 BC | Battle of Alesia; capitulation of Vercingetorix. | The decisive victory in the Gallic War. |
| 10 Jan 49 BC | Caesar crosses the Rubicon. | The beginning of the civil war against Pompey and the Republic; "the die is cast." |
| 48 BC | Battle of Pharsalus. | Caesar's decisive defeat of Pompey; murder of Pompey in Egypt. |
| 45 BC | Battle of Munda. | Caesar's final victory; sole rule over the Roman world. |
| 15 Mar 44 BC | Assassination of Julius Caesar (the Ides of March). | Caesar is stabbed; the conspiracy intended to save the Republic instead doomed it. |
| 43 BC | Second Triumvirate of Antony, Octavian and Lepidus; proscriptions (including Cicero). | The civil war among Caesar's heirs; the silencing of the Senate. |
| 42 BC | Battle of Philippi. | Defeat and death of the assassins Brutus and Cassius. |
| 31 BC | Battle of Actium. | Octavian defeats Antony and Cleopatra; the end of the civil wars; the Republic at an end. |
| 30 BC | Suicides of Antony and Cleopatra; annexation of Egypt. | Rome gains Egypt; Octavian is sole master. |
| 27 BC | Octavian granted the title "Augustus." | Foundation of the Roman Empire and the Principate. |
| Date | Event | Significance |
| AD 9 | Battle of the Teutoburg Forest (Varus); destruction of three legions by Arminius. | Rome's failure to conquer Germany; the Rhine became the permanent frontier. |
| AD 14 | Death of Augustus; succession of Tiberius. | The first peaceful succession of the empire. |
| AD 43 | Conquest of Britain by Claudius. | Roman Britain added to the empire. |
| AD 60/61 | Revolt of Boudicca in Britain. | A short-lived but violent rising crushed by Rome. |
| AD 64 | Great Fire of Rome (under Nero). | Destruction of much of the city; Nero's rebuilding; the persecution of Christians. |
| AD 69 | The Year of the Four Emperors; rise of Vespasian. | Civil war; foundation of the Flavian dynasty. |
| AD 70 | Destruction of the Temple of Jerusalem by Titus. | The end of the Jewish revolt; the diaspora; the arch of Titus commemorates it in Rome. |
| AD 79 | Eruption of Vesuvius; destruction of Pompeii and Herculaneum. | The famous disaster preserved the cities as documents of Roman life. |
| AD 96–180 | The "Five Good Emperors" (Nerva to Marcus Aurelius). | The golden age of the Pax Romana. |
| AD 117 | Greatest extent of the Roman Empire under Trajan. | The empire at its maximum; from Britain to Mesopotamia. |
| AD 122 | Hadrian builds Hadrian's Wall. | The frontier of Roman Britain; a symbol of imperial consolidation. |
| AD 180 | Death of Marcus Aurelius. | Conventional end of the Pax Romana; his son Commodus succeeds. |
| Date | Event | Significance |
| AD 193 | Year of Five Emperors; Septimius Severus founds the Severan dynasty. | Military monarchy; commencement of the end of the old order. |
| AD 212 | Constitutio Antoniniana: citizenship granted to all free inhabitants. | The universalisation of Roman citizenship; end of the old distinction. |
| AD 235–284 | The Crisis of the Third Century. | Civil war, invasion, plague and inflation; the empire nearly dissolved. |
| AD 260 | Capture of the emperor Valerian by the Persians. | The humiliation of Rome; the eastern threat became mortal. |
| AD 260–272 | The Gallic and Palmyrene breakaway empires. | The empire briefly split into three parts. |
| AD 270–275 | Reign of Aurelian; reconquest; building of the Aurelian Walls. | The beginning of recovery; the "restorer of the world." |
| AD 284–305 | Reign of Diocletian; the Tetrarchy; the Great Persecution. | Radical reform of the state; division into four; persecution of Christianity. |
| AD 312 | Battle of the Milvian Bridge; conversion of Constantine. | Constantine's rise; the Christianisation of the empire begun. |
| AD 313 | Edict of Milan (religious tolerance for Christianity). | End of the persecutions; Christianity's freedom. |
| AD 325 | Council of Nicaea. | Definition of the Christian creed at the emperor's summons. |
| AD 330 | Dedication of Constantinople. | Foundation of the new imperial and Christian capital. |
| Date | Event | Significance |
| AD 378 | Battle of Adrianople. | Defeat and death of Valens at the hands of the Goths; Rome’s military power shaken. |
| AD 380 | Edict of Thessalonica: Christianity made the official religion. | The pagan-old Roman religion finally displaced. |
| AD 395 | Final division of the empire between Arcadius (east) and Honorius (west). | Division of the empire into east and west. |
| AD 406 | Barbarians cross the Rhine. | The permanent loss of the western provinces begins. |
| AD 410 | Visigoths under Alaric sack Rome. | Rome falls to an enemy for the first time in 800 years; a profound psychological shock. |
| AD 451 | Battle of the Catalaunian Plains (Aetius vs. Attila). | Attila the Hun is checked in Gaul. |
| AD 452 | Attila invades Italy. | Devastation of northern Italy; tradition of the intervention of Pope Leo I. |
| AD 455 | Sack of Rome by the Vandals under Gaiseric. | The second sack of Rome; the origin of "vandalism." |
| 476 AD | Deposition of Romulus Augustulus by Odoacer. | The conventional "fall of the Western Roman Empire." |
| 1453 | Fall of Constantinople to the Ottomans. | End of the Byzantine (Eastern Roman) Empire; the end of the Roman state of all. |